this saying has its origins in the 70s love movement and was made really famous by Cheech & Chong in the 80s through their marijuanha films.

It does not mean OMG or awesome. It's a stand-alone phrase, usually preceding the phrase that will describe the object or situation that's freaking you out, blowing you away or leaving you at a loss for words.

It's present tense, denoting something that's actually happening and feels like it is beyond incredible.
Holy mother of pearl! Look at those tender young asses(on the beach);- cops in helicopter shadowing Cheech & Chong.

Holy mother of pearl! That's some serious shit.

Holy mother of pearl! That's one strong fuckin drink.

Holy mother of pearl! Did you see that?(a flying dog playing a guitar and shooting laserbeams from its eyes)

A spaceship appearing over London would leave you speechless, probably only with the ability to utter the words 'holy mother of pearl.'
Lanos Iceland tərəfindən 28 İyul 2011
9 Words related to Holy Mother of Pearl
sex, drugs, and alcohol
thats a holy mother of pearl.
frank mazouskii tərəfindən 11 Fevral 2008

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