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1.
A particularly unpleasant hangover.
"Last night was great, but I have the worst case of the irish flu today."
Melissa tərəfindən 10 İyul 2004
 
2.
A hangover, usually involving whiskey; may be mild or severe
"I’ve still got a touch of the Irish flu."

"The Irish flu?"

"Also known as a hangover."

(from "A Nose for Murder" by Lee Charles Kelley
Lee Charles Kelley tərəfindən 06 Aprel 2005
 
3.
The ailment one suffers on March 18th after properlyly celebrating St. Patrick's Day. Anyone of Irish descent may also use the term to denote a hangover on any day of the year.
Seamus: Ugh, I was out drinking Guinness until the wee hours. I think I'll call in with the Irish Flu today.
robbie vienna tərəfindən 17 Mart 2009